Prednisolone topically and systemically; a clinical evaluation in selected dermatosea: preliminary report.

Abstract

Prednisolone and prednisone, formerly called metacortandralone and metacortandracin, are two new synthetic hormones, which, milligram for milligram, possess greater anti-inflammatory effect and activity than cortisone or hydrocortisone and do not produce sodium and fluid retention or potassium depletion. Prednisolone is produced by dehydrogenation at Positions 1 and 2 of the hydrocortisone nucleus. It is an analogue of hydrocortisone, while prednisone is an analogue of cortisone and is produced by dehydrogenation at Positions 1 and 2 of the cortisone nucleus. As part of a research project to determine the effects of the various corticosteroids on skin electrolytes, the following is a preliminary report on the clinical effects of both topical and oral administration of prednisolone in a variety of dermatologic disorders. METHODS AND MATERIALS Topical Administration .—Prednisolone in strengths of 0.25% and 0.5% was prepared in an ointment of petrolatum and liquid