Abstract
Monolithic controlled release devices have been designed to take advantage of the two-phase morphology of a block copolyurethane. The release of prednisolone from copolyurethane devices fabricated by two different methods (solution casting and swelling in saturated solute solutions) was characterized. Higher release rates were obtained when prednisolone was primarily loaded in the hydrophilic polyether matrix as compared to being loaded throughout the copolyurethane. The release mechanisms were different from the two devices. As a possible contributing variable to the release mechanisms, intermolecular interactions between the solute and copolymer were also investigated. Intermolecular interactions between prednisolone and the urethane segment of the copolyurethane contributed to the lower release rates from the solution-cast devices. These interactions were absent in the devices loaded by swelling, which exhibited higher release rates.
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