Abstract
This study examined the socio-demographic, lifestyle, gynecological, and obstetric factors associated with serum or plasma concentrations of homocysteine, folic acid, and vitamins B12 and B6 among low-income women in São Paulo, Brazil. Serum concentrations of folic acid and vitamin B12 were measured by fluoroimmunoassay, while plasma vitamin B6 and homocysteine levels were measured by reversed-phase high performance liquid chromatography. Independent variables were initially selected by Pearson correlation or Kruskal-Wallis test (p < 0.20). Based on cut-off values, altered concentrations of homocysteine, folic acid, and vitamins B12 and B6 were found in 20%, 6%, 11%, and 67% of participants, respectively. Age was positively correlated with vitamin B6 and homocysteine plasma concentrations (p < 0.001). Body mass index was positively correlated with vitamin B6 plasma concentration (p < 0.001). Multiple linear regression models accounted for 10.2%, 5.8%, 14.4%, and 9.4% of folic acid, vitamins B12 and B6, and homocysteine plasma or serum concentrations, respectively. In this study, socio-demographic, lifestyle, gynecological, and obstetric variables showed important predictive value for serum or plasma levels of the biochemical indicators assessed.
Highlights
Os micronutrientes podem ter importante papel na melhoria da saúde reprodutiva de mulheres de países em desenvolvimento 1
This study examined the socio-demographic, lifestyle, gynecological, and obstetric factors associated with serum or plasma concentrations of homocysteine, folic acid, and vitamins B12 and B6 among low-income women in São Paulo, Brazil
Serum concentrations of folic acid and vitamin B12 were measured by fluoroimmunoassay, while plasma vitamin B6 and homocysteine levels were measured by reversed-phase high performance liquid chromatography
Summary
O presente estudo é do tipo transversal, de base hospitalar. Foram utilizados dados de um estudo caso-controle sobre dieta e lesões neoplásicas do colo uterino realizado entre março de 2003 e maio de 2005. Utilizou-se um questionário sobre informações médicas, demográficas, estilo de vida (tabagismo, consumo de bebidas alcoólicas, café e atividade física) e história ginecológica e obstétrica. Para estimativa do gasto energético em atividades físicas habituais, utilizou-se questionário estruturado com reprodutibilidade conhecida (coeficientes de correlação de Spearman variando de 0,51 a 0,82) 19. Medidas de peso (kg) e estatura (cm) foram realizadas em balança digital modelo BE03, capacidade para 150kg e precisão de 100g (marca Soehnle, Murrhardt, Alemanha) e em antropômetro extensível de parede com precisão de 0,1cm (modelo 208, marca SECA, Birmingham, Reino Unido), respectivamente. O índice de massa corporal (IMC), quociente do peso pela estatura ao quadrado (kg/m2), foi utilizado para avaliação antropométrica, com classificação de magreza (< 18,5), eutrofia (18,5 a 24,9), sobrepeso (25,0 a 29,9) e obesidade (≥ 30), conforme critérios propostos pela Organização Mundial da Saúde (OMS) 21
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