Predisposing factors of kidney function recovery after postrenal obstruction

Abstract

Background: Renal function recovery in postrenal acute kidney injury (AKI) patient is not always achieved and risk factor for chronic disease. Factors that affect of kidney function recovery include duration of symptoms, AKI stage and degree of hydronephrosis. The aim of the study is to determine the correlation of predisposing factors of renal function recovery in postrenal AKI patient.Methods: A prospective observational analytic study with a cross-sectional study approach that involves postrenal AKI with urinary tract stones formers from August to November 2017. Renal function recovery was assessed by comparing creatinine levels before obstruction and after obstruction (3rd and 7th day) and be correlated by the duration of symptoms, AKI stage, and degree of hydronephrosis.Results: 66 patients were included in the analysis of this study. Renal function recovery was found in 29 patients (43.9%) at 3rd day and 47 patients (71.2%) on the 7th-day post obstruction. There was a significant difference in mean creatinine levels before and after obstruction (p <0.0001). Both duration of symptoms, AKI stage, and hydronephrosis showed correlation on renal function recovery on 3rd and 7th day after obstruction (p < 0.05). In logistic regression analysis, hydronephrosis was the most correlated predisposing factor for renal function recovery in 3rd and 7th day after obstruction (p = 0.0001).Conclusion: Factors duration of symptoms, AKI stage, and degree of hydronephrosis significant correlated to renal function recovery after post-renal AKI. Degree of hydronephrosis was the most correlated predisposing factors.