Predictors to quality of life improvements in patients with chronic coronary total occlusion depending on the selected treatment strategy

Abstract

Highlights. The impact of clinical, angiographic and procedure-related factors on the quality of life of patients with chronic coronary total occlusions has been reported.Background. The impact of patient-related factors including clinical and angiographic data and procedure-related factors on the quality of life remains debating.Aim. To assess the impact of baseline and procedure-related factors on the quality of life in patients with chronic coronary total occlusion.Methods. 140 patients with chronic single-vessel disease randomly assigned either to the invasive-strategy group or the conservative-strategy group. Quality of life was measured in all patients using the Seattle Angina Questionnaire, European Quality of Life Survey, and Rose Dyspnea Scale after 3 and 12 months. To determine the predictors to the quality of life improvements in both groups, simple and multivariate regression analysis were performed. The baseline clinical, angiographic and procedure-related factors were included in the analysis.Results. The technical success of the procedure was the independent predictor to quality of life improvement in the invasive-strategy group (OR: 5.8, 95%, CI: 3,26-9.18, p = 0.001). The absence of diabetes mellitus (OR: 0.19, 95%, CI: 0.09-0.84, p = 0.04), CTO of other than left anterior descending artery (OR: 2.1, 95%, CI: 1.09-4.0, p = 0.03) and higher SAQ - 7 score at baseline (OR: 1.1, 95%, CI: 1.04-1.21, p = 0.02) independently predicted the improvements in the quality of life. The indicators of quality of life between the subgroups of subintimal and intraluminal recanalization did not differ significantly in the long-term period. The total SAQ-7 score in the subintimal recanalization subgroup was 85.5 ± 9.1 versus 89.3 ± 9.6 in the intraluminal recanalization subgroup (p = 0.21).Conclusion. The decision on the management of patients with chronic coronary total occlusions should be made individually, taking into account baseline clinical and instrumental data. The recanalization technique does not affect the quality of life. Its choice should be made individually in order to achieve technical success.