Abstract
To identify the predictors of final visual outcome in cases with post-fever retinitis (PFR). This is a retrospective study of cases with diagnosis of post-fever retinitis. Colour fundus photograph and optical coherence tomography (OCT) parameters at presentation and final visit were analysed. Various factors at presentation [age, systemic illness, best-corrected visual acuity (BCVA), area of retinitis and hard exudates, OCT parameters], at final visit (OCT parameters) and the treatment modalities used were correlated with BCVA at final visit. Twenty-four eyes of 16 patients with PFR were included in the study. Median BCVA at presentation was 6/60 and at final visit was 6/9. By multiple linear regression after adjusting for other variables, for every 1 unit increase in height of subretinal fluid (SRF) at fovea at presentation, the value of final BCVA decreased by 0.001 unit. For every 1 unit increase in extent of ellipsoid zone (EZ) loss and subfoveal deposit height, the value of final BCVA decreased by 0.0001 unit and 0.004 unit, respectively. The baseline OCT parameters that had negative correlation with final BCVA included central macular thickness (r: - 0.5182, p: 0.02), maximum SRF height (r: - 0.5539, p < 0.01) and SRF height at fovea (r: - 0.582, p < 0.01). The OCT parameters at final visit which had a negative correlation with final BCVA included disorganisation of retinal inner layers (DRIL) within 1000 microns from centre of fovea (r: - 0.6494, p < 0.01), height of subfoveal deposit (r: - 0.7627, p < 0.01), horizontal extent of subfoveal deposit (r: - 0.6695, p < 0.01) and extent of EZ loss (r: - 0.8216, p < 0.01). Height of SRF at presentation, extent of EZ loss and subfoveal deposit height at final visit were associated with poor final BCVA in PFR.
Highlights
Post fever retinitis (PFR) is a term used to describe the posterior segment manifestations following a febrile illness.[1,2] It is a relatively newer entity, described in literature by various names like epidemic retinitis, post febrile retinitis, acute multifocal retinitis and post febrile uveitis.[1,2,3] Patients with PFR typically develop unilateral or bilateral retinitis after 2-4 weeks of febrile illness.[4]
Various factors at presentation [age, systemic illness, best corrected visual acuity (BCVA), area of retinitis and hard exudates, optical coherence tomography (OCT) parameters], at final visit and the treatment modalities used were correlated with BCVA at final visit
For every 1 unit increase in extent of ellipsoid zone (EZ) loss and subfoveal deposit height, the value of final BCVA decreased by 0.0001unit and 0.004 unit respectively
Summary
Post fever retinitis (PFR) is a term used to describe the posterior segment manifestations following a febrile illness.[1,2] It is a relatively newer entity, described in literature by various names like epidemic retinitis, post febrile retinitis, acute multifocal retinitis and post febrile uveitis.[1,2,3] Patients with PFR typically develop unilateral or bilateral retinitis after 2-4 weeks of febrile illness.[4] It is characterized by the presence of unifocal or multifocal retinitis, predominantly involving the posterior pole and peripapillary region. The factors predicting the visual outcome in post fever retinitis were analysed
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