Abstract
ObjectivesTo evaluate the left ventricular function before and after transcatheter percutaneous patent ductus arteriosus (PDA) closure, and to identify the predictors of myocardial dysfunction post-PDA closure if present. InterventionsTranscatheter PDA closure; conventional, Doppler, and tissue Doppler imaging; and speckle tracking echocardiography. Outcome measuresTo determine the feasibility and reliability of tissue Doppler and myocardial deformation imaging for evaluating myocardial function in children undergoing transcatheter PDA closure. Patients and methodsForty-two children diagnosed with hemodynamically significant PDA underwent percutaneous PDA closure. Conventional, Doppler, and tissue Doppler imaging, and speckle-derived strain rate echocardiography were performed at preclosure and at 48hours, 1month, and 6months postclosure. Tissue Doppler velocities of the lateral and septal mitral valve annuli were obtained. Global and regional longitudinal peak systolic strain values were determined using two-dimensional speckle tracking echocardiography. ResultsThe median age of the patients was 2years and body weight was 15kg, with the mean PDA diameter of 3.11±0.99mm. M-mode measurements (left ventricular end diastolic diameter, left atrium diameter to aortic annulus ratio, ejection fraction, and shortening fraction) reduced significantly early after PDA closure (p<0.001). After 1month, left ventricular end diastolic diameter and left atrium diameter to aortic annulus ratio continued to decrease, while ejection fraction and fractional shortening improved significantly. All tissue Doppler velocities showed a significant decrease at 48hours with significant prolongation of global myocardial function (p<0.001) and then were normalized within 1month postclosure. Similarly, global longitudinal strain significantly decreased at 48hours postclosure (p<0.001), which also recovered at 1month follow-up. Preclosure global longitudinal strain showed a good correlation with the postclosure prolongation of the myocardial performance index. ConclusionTranscatheter PDA closure causes a significant decrease in left ventricular performance early after PDA closure, which recovers completely within 1month. Preclosure global longitudinal strain can be a predictor of postclosure myocardial dysfunction.
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