Abstract
The objective of this study was to investigate the predictors for new-onset mental disorders among patients with mild to moderate COVID-19 illness during hospitalization. A retrospective cohort study was performed in patients with confirmed COVID-19 admitted to a nationally designated hospital between 1 February and 30 June 2020. Demographic, clinical, psychological assessments, and psychiatric outcomes were obtained from electronic medical record review. Multivariate logistic regression analysis was used to identify predictors of new-onset mental disorders. Among 185 patients, 130 had no history of mental disorders or cognitive impairment at the time of admission. Of 130 patients, 29 (22.3%) were newly diagnosed with mental disorders during hospitalization. The following factors were significantly associated with an increased risk of a psychiatric diagnosis: Charlson comorbidity index core ≥1 (adjusted odds ratio (aOR) = 5.115, 95% confidence interval (CI): 1.737–15.058), length of stay (aOR per 1-day increase = 1.067, 95% CI: 1.035–1.100), and self-reported depressive symptoms at the time of admission (aOR = 5.357, 95% CI: 1.745–16.444). The predictive accuracy of combining these risk factors was relatively high (area under curve = 0.851, 95% CI: 0.778–0.923). These potential risk factors could help to predict the new-onset mental disorder among hospitalized patients with COVID-19.
Highlights
Inclusion criteria of this study were laboratory-confirmed COVID-19 patients admitted to the isolation wards of the National Medical Center (NMC), Seoul, South Korea between 1 February and 30 June 2020 and COVID-19 patients who could complete the psychological questionnaires when admitted in the hospiPatients with a history of mental illness and those who were unable to the complete Int
A total of 185 patients with COVID-19 were admitted to the isolation wards of the NMC
We found 16.3% of the subjects had self-reported depressive symptom (PHQ-9 score ≥ 10 or PHQ-2 score 3) and 6.3% had self-reported post-traumatic stress disorder (PTSD) symptom (PCL-5 score ≥ 33 or PC-PTSD score ≥ 3) on admission
Summary
The objective of this study was to investigate the predictors for new-onset mental disorders among patients with mild to moderate COVID-19 illness during hospitalization. A retrospective cohort study was performed in patients with confirmed COVID-19 admitted to a nationally designated hospital between 1 February and 30 June 2020. Multivariate logistic regression analysis was used to identify predictors of new-onset mental disorders. There is a growing body of evidence that has identified a high incidence of developing psychological sequelae in patients with COVID-19. Survivors of the diseases reported anxiety or depression during the 6 months follow-up period [5]. A study using Korean health insurance claim data showed that COVID-19 survivors had a greater risk of developing mental illness than the rest of the population [6]
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