Predictors of Survival of Natural Killer/T-cell Lymphoma (NKTL), nasal type in a Peruvian Population at a Cancer Institute

Abstract

S66 we divided in three groups, the first group had 25 patients who received CHOP (10)/CHOEP (15) follow by external beam radiation, the second group had 12 patients who received external beam radiation followed by CHOP (8) or CHOEP (4)-based chemotherapy and the third group only had two patients who received concurrent radiotherapy plus CHOP-based chemotherapy. Variables were analyzed using univariate and multivariate analyses with CR as the dependent variable; it used Chi-square for comparing the risks among patient’s characteristics. Results: The mean of age was 37.72 years (14-68), males were 14 (35.9%), females were 25 (64.1%), stage I was 22 (56.4%), stage II were 17 (43.6%), B symptoms were 14 (35.9%), LDH above normal were 16 (41%), 6 patients received 1-3 CT cycles (15.4%), and 33 patients received 4-6 cycles(84.6%). Twenty-nine (74.4%) of 39 patients achieved CR. The group 1 had 76.0% (19/25) of CR, the group 2 had 75.0% (9/12), and the group 3 had 50% (1/2). Univariate analysis identified LDH and number of CT cycles, as significant predictors of CR (both P <0.05). On multivariate analysis, only number of CT cycles showed statistically significant, received 1-3 cycles of CHOP-based CT had an odds ratio (OR): 17.085, P1⁄4 0.026 being independent predictor. Conclusion: The number of CT cycles was the only CR predictor, and the fact of having received CT followed by RT or radiotherapy followed by CT as first-line did not influence the response.