Predictors of Sudden Cardiac Death In Acute Heart Failure With Preserved Ejection Fraction (hfpef), Analysis of Unitedstates Nationwide Inpatient Sample

Abstract

Background Prevalence and admissions related to acute heart failure with preserved ejection fraction (HFpEF) are rising. The literature on risk factors predicting SCD in patients with HFpEF is scarce Purpose The aim of this study is to identify risk factors related to SCD in HFpEF. Methods Nationwide Inpatient Sample from 2016-2017 was used for the study. We used ICD-10-CM codes to identify patients (age > 18) with acute HFpEF and excluded patients with secondary risk factors for SCD and the presence of implanted cardioverter defibrillator. After applying weights, two cohorts of HFpEF with and without SCD were compared using student t-test, chi-square, and multivariate regression. Results 323,710 patients with acute HFpEF were identified, out of which 1255(3.9%) had SCD. There was no difference in age (75.12 vs 74.77; p=0.67) and gender (females:60.96% vs 62.77%;p > 0.18) in both cohorts. Electrolyte disturbances(45.02% vs 30.37%; p Conclusions SCD is a significant cause of mortality in acute HFpEF. A better understanding of pathophysiologic patterns of HFpEF may improve outcomes in these patients.