Abstract
BackgroundHuman brucellosis remains to be a neglected zoonotic disease among agro-pastoral communities where livestock rearing is one of the main economic activities. This study was conducted in different agro-pastoral communities in Sengerema district, Mwanza, Tanzania, to determine seroprevalence and predictors of anti-Brucella antibodies, information that may influence public awareness on the risk factors and strategies to improve the diagnosis of brucellosis in developing countries.MethodsA cross-sectional community-based study was conducted between July and September 2008 in ten villages of Sengerema district. Sociodemographic and other related information were collected using a standardized data collection tool. Detection of Brucella abortus and Brucella melitensis antibodies were done using rapid Brucella serum agglutination test. Data were analysed by using STATA version 11.0. Adjusted odds ratios (AOR) were calculated using multivariate logistic regression analysis.ResultsA total of 382 adults were enrolled with the median age of 30 (interquartile range 15–40) years. Males formed the majority of the participants 234 (61.5 %). Overall, seroprevalence of anti-Brucella antibodies was found to be 14.1 % (54/382, 95 % CI 10.6–17.5). Seroprevalence of B. melitensis was 11 % (42/382) while that of B. abortus was found to be 7 % (26/282), P = 0.0267. Co-infection of B. melitensis and B. abortus was observed in 3.6 % (14/382, 95 % CI 1.7–5.4) of participants. On a multivariate logistic regression analysis, male sex (AOR 3.2, 95 % CI 1.3–7.5, P = 0.007), touching goat placenta (AOR 2.54, 95 % CI 1.05–6.14, P = 0.012) and agro-pastoralist occupation (AOR 2.07, 95 % CI 1.01–4.24, P = 0.04) were found to predict B. melitensis infection. Males (AOR 3.07, 95 % CI 1.45–6.51, P = 0.003) and agro-pastoralists (AOR 2.98, 95 % CI 1.38–6.43, P = 0.005) were found to be predictors for specific anti-Brucella antibodies.ConclusionsA significant proportion of the agro-pastoralist male population in agro-pastoral communities in Sengerema district is positive for anti-Brucella antibodies. With the decrease incidence of malaria fever, other causes of fever such as Brucella spp. should be considered of public health concern in Tanzania especially in agro-pastoral communities.
Highlights
Human brucellosis remains to be a neglected zoonotic disease among agro-pastoral communities where livestock rearing is one of the main economic activities
The Eurocell A® is specific for B. abortus and Eurocell M® for B. melitensis
Baseline characteristics A total of 382 participants from agro-pastoral communities in different villages of Sengerema district were recruited with the median age of 30 (interquartile range (IQR) 15–40) years
Summary
Human brucellosis remains to be a neglected zoonotic disease among agro-pastoral communities where livestock rearing is one of the main economic activities. This study was conducted in different agro-pastoral communities in Sengerema district, Mwanza, Tanzania, to determine seroprevalence and predictors of anti-Brucella antibodies, information that may influence public awareness on the risk factors and strategies to improve the diagnosis of brucellosis in developing countries. Human brucellosis is a global public health concern due to its potential in causing morbidity among human population as well as livestock leading to economic loses. Over 500,000 human cases of brucellosis are reported annually [1]. In the tropical countries like Tanzania, Brucella infection is endemic especially in agro-pastoral communities [2]. Brucellosis is an occupational disease to slaughterhouse workers, agro-pastoralists, laboratory personnel and veterinarians [3]. Humans can get infection through direct contact with infected farm animals or ingestion of contaminated animal products [4, 5]
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