Abstract
BackgroundAlthough several determinants of global developmental delay (GDD) have been recognized, a significant number of children remain without definitive etiologic diagnosis. The objective of this study was to assess the effect of various prenatal and perinatal factors on the severity and outcome of developmental delay without definitive etiologic yield.MethodsFrom March 2008 to February 2010, 142 children with developmental quotient (DQ) <70 and without definitive etiologic diagnosis, were included. Prenatal and perinatal risk factors known to be associated with disordered neonatal brain function were identified. Participants underwent a thorough investigation, an individualized habilitation plan was recommended, and the children were followed-up regularly for a period of 2 < years. The effect of prenatal and perinatal risk factors on the severity and outcome of GDD was assessed by regression analysis.ResultsThe mean age at enrolment was 31 ± 12 < months, and the mean DQ 52.2 ± 11.4. Prematurity and intrauterine growth restriction (IUGR) were found to be independently associated with lower DQ values. The mean DQ after the 2-year follow-up was 62.5 ± 12.7, and the DQ difference from the enrollment 10.4 ± 8.9 (median 10; range-10 to 42). DQ improvement (defined as a DQ difference?≥?median) was noted in 52.8% of the children. IUGR, low socio-economic status, and poor compliance to habilitation plan were found to be independently associated with poorer developmental outcomes.ConclusionsPrematurity and IUGR were found to be significantly and independently related to the severity of GDD in cases without definitive etiologic yield. Poorer 2-year developmental outcome was associated with IUGR, low socioeconomic status and non compliance to habilitation plan. Prematurity was a significant determinant of the outcome only in association with the above mentioned factors.
Highlights
Several determinants of global developmental delay (GDD) have been recognized, a significant number of children remain without definitive etiologic diagnosis
During the inclusive period, a total of 296 children younger than 5 years of age were referred for suspected developmental delay to our Developmental Pediatric Department and were consecutively screened for enrolment in the study
The developmental quotient (DQ) of children initially assessed by the Bayley Scales of Infant Development (N = 88) was 51.7 ± 10.9, whereas of those assessed by Griffiths Scales for Mental Development and Athina Test 53 ± 13.5 (P = 0.530)
Summary
Several determinants of global developmental delay (GDD) have been recognized, a significant number of children remain without definitive etiologic diagnosis. The objective of this study was to assess the effect of various prenatal and perinatal factors on the severity and outcome of developmental delay without definitive etiologic yield. Disordered neonatal brain function is associated with a number of risk factors, including but not limited to perinatal hypoxia-ischemia [13,16,17,18]. Many of these factors may be preventable or modifiable, and their prompt identification may have significant clinical and prognostic implications [13]
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