Abstract
Background. Chronic obstructive pulmonary disease (COPD) patients have multiple comorbidities which may affect renal function. Chronic kidney disease (CKD) is a risk factor for adverse outcomes in COPD patients. The predictors of CKD in COPD are not well investigated. Methods. A multicenter observational cohort study including patients affected by COPD (GOLD stages 1 and 2) was carried out. Principal endpoints were the incidence of CKD, as defined by an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2, and the rapid decline of eGFR >5 mL/min/1.73 m2/year. Results. We enrolled 707 outpatients. Overall, 157 (22.2%) patients had CKD at baseline. Patients with CKD were older, with higher serum uric acid (UA) levels, and lower FEV1. During a mean follow-up of 52.3 ± 30.2 months, 100 patients developed CKD, and 200 patients showed a rapid reduction of eGFR. Multivariable Cox regression analysis displayed that UA (hazard ratio (HR) 1.148, p < 0.0001) and diabetes (HR 1.050, p < 0.0001) were predictors of incident CKD. The independent predictors of rapidly declining renal function were represented by an increase of 1 mg/dL in UA (odds ratio (OR) 2.158, p < 0.0001)), an increase of 10 mL/min/1.73 m2 in baseline eGFR (OR 1.054, p < 0.0001) and the presence of diabetes (OR 1.100, p < 0.009). Conclusions. This study shows that COPD patients have a significant worsening of renal function over time and that UA and diabetes were the two strongest predictors. Optimal management of these risk factors may reduce the incidence of CKD in this population thus probably improving clinical outcome.
Highlights
The interesting findings of our present study, referring to a large number of Chronic obstructive pulmonary disease (COPD) patients, suggests that uric acid (UA) represents an independent predictor of chronic kidney disease (CKD) occurrence and rapidly progressive decline in renal function
The disease association including COPD, hyperuricemia and kidney failure persists even after correction for the known risk factors involved in renal damage (Figure 2)
UA measurement could be suitable for the detection of COPD subjects who are at high risk of developing renal function deterioration, highlighting the importance of creatinine monitoring
Summary
Cardiovascular (CV) and non-cardiovascular comorbidities such as hypertension, diabetes, cognitive decline, osteoporosis/osteopenia, chronic kidney disease (CKD) and cancer [3,4]. The pathogenesis of CKD includes atherosclerotic damage, due to activation of proinflammatory and pro-oxidant pathways leading to pathologic changes in renal circulation [7,8,9]. Chronic obstructive pulmonary disease (COPD) patients have multiple comorbidities which may affect renal function. Chronic kidney disease (CKD) is a risk factor for adverse outcomes in COPD patients. The predictors of CKD in COPD are not well investigated
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