Abstract
Background: Hepatocellular carcinoma is the third leading cause of tumor related mortality and develops mostly in patients with chronic liver disease and liver cirrhosis. Human hepatocyte growth factor (HGF) is produced in various organs of the body and is characterized as a multifunctional factor with various biologic activities. Aim: Our aim was to investigate the predictive factors of recurrence specially the role of HGF in patients with HCC treated with TACE. Patients and Methods: one hundred HCC patients treated by TACE who achieved complete response were included and divided into two groups according to disease free survival (DFS) status at 1 year: the non-early recurrence (NER) group (1) and the early recurrence (ER) group (2). Univariate binary logistic regression analysis for the possible risk factors of recurrence showed that AFP, multinodularity and HGF level were significant. Conclusion: high AFP, multinodularity and high HGF were inter-related possible risk factors for 1-year recurrence of HCC in patients with initial remission following TACE.
Highlights
Hepatocellular carcinoma is the third leading cause of tumor related mortality after tumors of the lung and the stomach [1] and the prevalence is high in subSaharan Africa and Southeast Asia
Univariate binary logistic regression analysis for the possible risk factors of recurrence showed that AFP, multinodularity and hepatocyte growth factor (HGF) level were significant
Comparison between the two groups: group (1) non early recurrence (NER) and group (2) early recurrence (ER), showed no significant difference in terms of age, sex, size of the tumor, aetiology of liver cirrhosis and liver function but AFP level, number of the lesions and HGF level were significantly higher in the ER group compared with the other group (p value < 0.001, 0.001, 0.001) (Table 1)
Summary
Hepatocellular carcinoma is the third leading cause of tumor related mortality after tumors of the lung and the stomach [1] and the prevalence is high in subSaharan Africa and Southeast Asia. It develops mostly in patients with chronic liver disease and liver cirrhosis [2]. Hepatocellular carcinoma is the third leading cause of tumor related mortality and develops mostly in patients with chronic liver disease and liver cirrhosis. Conclusion: high AFP, multinodularity and high HGF were inter-related possible risk factors for 1-year recurrence of HCC in patients with initial remission following TACE
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