Abstract
Background Premature rupture of membranes (PROM) is a common condition in developed and developing countries and poses a serious threat to the maternal and fetal well-being if not properly managed. This study delineated the prevalence and predictors of PROM in the western part of Uganda so as to guide specific preventive measures. Methods A cross-sectional study design was conducted in the months of September 2019 to November 2019. A total of 334 pregnant women above 28 weeks of gestation admitted at the maternity ward of KIU-TH were consecutively enrolled. Interviewer-administered questionnaires were used to obtain the data. Descriptive statistics followed by binary logistic regression were conducted. All data analyses were conducted using STATA 14.2. Results Of the 334 pregnant women enrolled, the prevalence of PROM was found to be 13.8%. The significant independent predictors associated with lower odds of PROM were no history of urinary tract infection (UTI) in the month preceding enrollment into the study (aOR = 0.5, 95% CI: 0.22-0.69, p = 0.038) and gestational age of 37 weeks or more (aOR = 0.3, 95% CI: 0.14-0.71, p = 0.038) and gestational age of 37 weeks or more (aOR = 0.3, 95% CI: 0.14-0.71, p = 0.038) and gestational age of 37 weeks or more (aOR = 0.3, 95% CI: 0.14-0.71, Conclusions Majorly urinary tract infections, low gestational age, and abortions influence premature rupture of membranes among women. There is a great need for continuous screening and prompt treatment of pregnant women for UTI especially those with history of 3 or more abortions at less than 34 weeks of gestation.
Highlights
Premature rupture of membranes (PROM) is defined as the spontaneous rupture of the fetal membranes prior to onset of labour [1]
Of the 334 pregnant women enrolled in the study, the overall prevalence of premature rupture of membranes was 46 (13.8%), with 25 (7.5%) participants with preterm premature rupture of membranes (PPROM) and 21 (6.3%) with term premature rupture of membranes (TPROM)
This study found that history of urinary tract infections, number of abortions, and gestational age were the independent predictors of premature rupture of membranes among pregnant women above 28 weeks of gestation admitted at Kampala International University Teaching Hospital (KIU-TH)
Summary
PROM is defined as the spontaneous rupture of the fetal membranes prior to onset of labour [1]. The efforts of various scholars have continued to demonstrate the association of various obstetric and gynaecologic factors with premature rupture of membranes such as prior history of PROM or preterm labour, genital infections, prior abortions, multiple gestation, polyhydramnios, and prior cervical procedures [11,12,13,14,15] among others. The significant independent predictors associated with lower odds of PROM were no history of urinary tract infection (UTI) in the month preceding enrollment into the study (aOR = 0:5, 95% CI: 0.22-0.69, p = 0:038) and gestational age of 37 weeks or more (aOR = 0:3, 95% CI: 0.14-0.71, p = 0:01) while history of 3 or more abortions (aOR = 13:1, 95% CI: 1.12-153.62, p = 0:05) was associated with higher likelihood of PROM. There is a great need for continuous screening and prompt treatment of pregnant women for UTI especially those with history of 3 or more abortions at less than 34 weeks of gestation
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