Abstract
This study sought to identify predictors for poor adherence to medication among patients with first-episode schizophrenia-spectrum disorder. Medication adherence was measured 1 and 2 years after initiation of antipsychotic medication in a follow-up study of 547 patients. Relevant variables were systematically assessed at baseline, 1- and 2-year follow up. Most patients have difficulties with medication adherence over time. Negative attitudes towards medication and lack of consistent family support are the strongest predictors for poor adherence to medication for first-episode psychotic patients in the first 2 years. After 1 year of treatment, unawareness of the effect of medication, lack of positive attitudes towards medication, substance abuse, young age and high global functioning also predict poor adherence to medication. A number of variables were independently associated with poor adherence. Rating of insight and attitudes towards medication makes it possible to predict poor adherence in incident cases with schizophrenia.
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