Abstract
Survival rates in patients with intermittent claudication and in patients with critical leg ischemia (CLI) have never been compared directly in a western population, and no report has yet determined the prognostic significance of the 2 clinical presentations of peripheral arterial disease (PAD) in long-term follow-up. Most observational studies have examined patients with critical1,2 and noncritical3–7 leg ischemia separately, or have reported the prognostic value of the ankle-brachial blood pressure index.8–11 We conducted a study to determine whether CLI is an independent risk factor for all-cause and cardiovascular mortality, paying attention to the confounding effect of other prognostic factors, including traditional cardiovascular risk factors and concomitant cardiac and cerebrovascular disease.
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