Predictors of outcome in hypoglycemic encephalopathy

Abstract

AimsThe aim of this study was to investigate factors predicting poor prognosis in patients with hypoglycemic encephalopathy. MethodsWe retrospectively analyzed data on 165 consecutive patients with hypoglycemic encephalopathy. We evaluated their outcome 1 week after hypoglycemia onset using the Glasgow outcome scale (GOS) and compared the clinical features of patients with good outcomes (GOS=5) and poor outcomes (GOS≤4). ResultsThe poor-outcome group included 38 patients (23%). The initial blood glucose level in the poor-outcome group was lower than that in the good-outcome group (p=0.002). The duration of hypoglycemia in the poor-outcome group was longer than that in the good-outcome group (p<0.001). Body temperature during hypoglycemia in the poor-outcome group was higher than that in the good-outcome group (p<0.001). Furthermore, lactic acid level in the poor-outcome group was lower than in the good-outcome group (p=0.032). There was no significant difference in the frequency of posttreatment hyperglycemia between the good-outcome and poor-outcome groups (p=0.984). ConclusionProfound and prolonged hypoglycemia, normal or higher body temperature, and a low lactic acid level during hypoglycemia may be predictors of a poor outcome in patients with hypoglycemic encephalopathy.