Predictors of Outcome in HIV-associated Primary Effusion Lymphoma

Abstract

25 (64.1%), stage I was 22 (56.4%), stage II were 17 (43.6%), B symptoms were 14 (35.9%), LDH above normal were 16 (41%), 6 patients received 1-3 CT cycles (15.4%), and 33 patients received 4-6 cycles(84.6%). Twenty-nine (74.4%) of 39 patients achieved CR. The group 1 had 76.0% (19/25) of CR, the group 2 had 75.0% (9/12), and the group 3 had 50% (1/2). Univariate analysis identified LDH and number of CT cycles, as significant predictors of CR (both P <0.05). On multivariate analysis, only number of CT cycles showed statistically significant, received 1-3 cycles of CHOP-based CT had an odds ratio (OR): 17.085, P ¼0.026 being independent predictor. Conclusion: The number of CT cycles was the only CR predictor, and the fact of having received CT followed by RT or radiotherapy followed by CT as first-line did not influence the response. Keywords: Natural Killer/T-cell lymphoma; Prognostic index; chemotherapy.