Predictors of outcome after surgery in 134 children with drug-resistant TLE

Abstract

PurposeTo determine the factors predicting seizure outcome in children who underwent anterior temporal lobectomy (ATL) for drug-resistant temporal lobe epilepsy (TLE). MethodsAmong the 664 patients who underwent ATL for TLE from 1995 to 2008, there were 134 children. “Excellent” outcome in them was defined as seizure freedom during the entire follow-up (Engel class I a); “good outcome”, if in remission last 2 years, and the rest as “unfavorable outcome”. To identify the potential predictors of seizure recurrence, the attributes of recurred and non-recurred groups was compared by univariate and multivariate analysis. ResultsOf the 134 children, at a mean post-operative follow-up of 8.1 years, there were 82 (61.1%) with excellent outcome and 26 (19.4%) with good outcome (category-1; seizure-free, 80.6%). Drugs could be successfully withdrawn in 69 (63.9%). 26 patients (22.4%) had seizure recurrence, (category-2, treatment/surgical failure).Whereas, of the 530 adults who underwent ATL during this time period, only 46.8% never had seizures (category-1) and 53.2% had seizure recurrence in the form of acute post-operative seizures or auras or habitual or non-habitual seizures (category-2).The hazard of seizure recurrence in children increased with positive family history of seizures and /or epilepsy, normal neuroimaging, spikes in post-operative EEG at 3-months, normal histopathology and duration of epilepsy ≥5 years. ConclusionsThe information on the predictive factors causing seizure recurrence/freedom in children with drug-resistant TLE is important in surgical selection. Surgery for pediatric TLE results in favorable outcome, hence one should subject children for resective surgery at the earliest especially in lesions known to cause refractoriness.