Abstract
Objective: To determine the predictors of absence of lesion on cone biopsy (white cone). We evaluated several factors including parity, cytology, human papillomavirus (HPV) typing, biopsy, colposcopy, smoking habit, use of oral contraceptive or condom, and immunosuppression as predictors for absence of dysplasia. Methods: Of 510 patients with CIN (cervical intraepithelial neoplasia) treated by loop electrosurgical excision (LEEP) in the Fundación Jimenez Diaz hospital between 2012 and 2016, 51 (10%) patients had a white cone and were defined as the study group. The control group was established from two randomly selected controls for each case (n = 102). Results: The study group had a higher prevalence of low-grade cytology (p 0.001), minor changes (p 0.01), and CIN 2 ( = 0.005), as demonstrated by the multivariate analysis (except for low-grade cytology). Conclusions: In conclusion, this study indicates that the incidence of white cone in our institution is 10% of all the cone biopsy and women with low-risk cytology, minor changes in colposcopy, CIN 2, and no use of oral contraceptive have a high probability of having no lesions in the conization specimen.
Highlights
Cervical intraepithelial neoplasia (CIN) is a premalignant condition of the cervix
We evaluated several factors including parity, cytology, human papillomavirus (HPV) typing, biopsy, colposcopy, smoking habit, use of oral contraceptive or condom, and immunosuppression as predictors for absence of dysplasia
The study group had a higher prevalence of low-grade cytology (p < 0.001), minor changes (p < 0.01), and CIN 2 (
Summary
Five hundred and ten cone biopsies were carried out in the department of gynaecology and obstetrics of the Fundación Jimenez Diaz University Hospital. These procedures were performed from January 2012 to February 2016 by five different gynaecologists from the lower genital-tract pathology department, each having the same level of training. The study group included patients with a negative histology in the conization specimen (n = 51) and CIN stage 2 - 3 on previous colposcopy-guided biopsy. We included two randomly selected controls for each case; 102 controls were se-
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