Predictors of Mechanical Ventilation Among 1960 Obese Patients Admitted With Guillain-Barré syndrome in the United States (P12-8.015)

Abstract

<h3>Objective:</h3> To understand the impact of obesity on the need for mechanical ventilation following admission for Guillain-Barré syndrome (GBS) and the associated risk of mortality. <h3>Background:</h3> Obesity is a fast-growing risk factor predisposing to many complications. Its impact on the outcomes of GBS patients has not been properly reported in the literature. <h3>Design/Methods:</h3> Obese patients with a principal diagnosis of GBS were pooled from the 2019 National Inpatient Sample. Logistic regression models, adjusting for confounders, were used to identify potential risk factors for requiring mechanical ventilation and overall mortality risk. <h3>Results:</h3> A total of 1960 obese patients with GBS were admitted in 2019, and 240 (12.2%) required mechanical ventilation. Arthropathies (aOR 4.876, 95% CI 2.582–9.206, p&lt;0.01), chronic pulmonary disease (aOR 2.223, 95% CI 1.505–3.283, p&lt;0.01), acute kidney injury (aOR 6.068, 95% CI 4.047–9.097, p&lt;0.01), ventricular tachycardia (aOR 3.401, 95% CI 1.353–8.549, p&lt;0.01), and paroxysmal atrial fibrillation (aOR 8.176, 95% CI 4.608–14.505, p&lt;0.01) were potential risk factors for requiring mechanical ventilation. Meanwhile hypothyroidism (aoR 0.370, 95% CI 0.216–0.634, p&lt;0.01), diabetes (aOR 0.611, 95% CI 0.398–0.936, p=0.024), and patients covered by Medicaid (aOR 0.351, 95% CI 0.184–0.669, p&lt;0.01), or private insurances (aOR 0.557, 0.351–0.883, p=0.013) (compared to Medicare) were at lower risk. Obese GBS patients using mechanical ventilation also had a higher risk of death (10.4% vs. 0.9%, aOR 47.586, 95% CI 12.334–169.823, p&lt;0.01). <h3>Conclusions:</h3> Several factors influence the risk of requiring mechanical ventilation among obese GBS patients. Obese patients using mechanical ventilation were at risk of poorer outcomes. <b>Disclosure:</b> Dr. Sanikommu has nothing to disclose. Dr. Sombans has nothing to disclose. Dr. Ramphul has nothing to disclose. Dr. Verma has nothing to disclose. Dr. Kumar has nothing to disclose. Dr. Ramphul has nothing to disclose. Dr. Meena has nothing to disclose. Dr. Kumari has nothing to disclose. Dr. Gonzalez Mejias has nothing to disclose. Dr. Jairam Das Lohana has nothing to disclose. Dr. Arti has nothing to disclose.