Abstract
Background:
 Coronavirus Disease 2019 (COVID-19) is caused by novel coronavirus Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The mortality of patients in the Intensive Care Unit (ICU) is variable and has been reported to be as high as 80%. Not much is known about the factors leading to the progression of hospitalized patients to requiring ICU care and the predictors of mortality among ICU patients. We performed univariate followed by multivariate logistic regression analysis to determine predictors of progression of the disease and factors associated with mortality.
 
 Method:
 Retrospective data were collected from 101 consecutive patients admitted from March, 2020 to June, 2020. Data were collected from five different community hospitals in eastern Virginia with varied demographics.
 
 Result:
 A total of 101 consecutive hospitalized patients in five community hospitals in eastern Virginia were enrolled in the study. Out of the 101 patients, 53 were admitted into the ICU for respiratory failure. Of these 53, 40 patients required intubation and mechanical ventilation. Altogether, 30 of the 53 patients admitted to the ICU died. Of these 30 patients, 25 required intubations. Of these 25 patients, one had mild, 6 moderate and 18 severe Adult Respiratory Distress Syndrome (ARDS). Patients aged 60 years and above accounted for >2/3rd of the cases in ICU.
 
 Conclusion:
 Logistic regression analysis revealed multiple factors associated with progression of disease leading to transfer into the ICU from floor and unfavorable outcome.
Highlights
The Coronavirus Disease 2019 (COVID-19) has wreaked havoc around the globe with unprecedented morbidity and mortality, with no end in sight
Total of 101 patients from five different community hospitals were enrolled in the study, of which 53 (52%) were treated in the medical Intensive Care Unit (ICU)
Our study found that patient with diabetes mellitus and hypertension along with elevated creatinine and C-reactive protein (CRP) on admission were predictors of clinical deterioration leading to ICU admission
Summary
The Coronavirus Disease 2019 (COVID-19) has wreaked havoc around the globe with unprecedented morbidity and mortality, with no end in sight. Researchers have consistently come up with two variables -- age and the need for mechanical ventilation -- as the potential markers of mortality, which is about 16-97%.2-6. Given the high mortality rate in the ICU, in patients with a combination of advanced age and the need for mechanical ventilator support,[6] providers have been searching for reasons leading to ICU admission altogether[7]. Not much is known about the factors leading to the progression of hospitalized patients to requiring ICU care and the predictors of mortality among ICU patients. Out of the 101 patients, 53 were admitted into the ICU for respiratory failure Of these 53, 40 patients required intubation and mechanical ventilation. 30 of the 53 patients admitted to the ICU died Of these 30 patients, 25 required intubations. Patients aged 60 years and above accounted for >2/3rd of the cases in ICU
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