Abstract
Active and chronic antibody-mediated rejection (AMR) is a common cause of graft failure. Prognostic markers of this complication are not well defined. We aimed to find out the demographic, histopathological and clinical characteristics of transplant recipients who developed AMR and to evaluate the impact of these features as well as antirejection treatment modalities on graft survival.
Highlights
Active and chronic antibody-mediated rejection (AMR) is a common cause of graft failure
Serum creatinine, proteinuria at time of biopsy, diffuse peritubular C4d stainig were significantly associated with graft survival
A statistically significant relationship was detected between creatinine, proteinuria, PRA percentage at the beginning of rejection and diffuse C4d staining in renal biopsy and graft survival
Summary
Active and chronic antibody-mediated rejection (AMR) is a common cause of graft failure. In previous reports the incidence of AMR has been defined to vary between 5.6% and 23%. AMR frequently occurs as a reaction to donor HLA antigens and seldom to non-HLA antigens [1,2]. B cell and plasma cell activation leads to the production of DSAs that bind to HLA or non-HLA molecules expressed on endothelial cells in the renal allograft [4]. Active AMR contributes to peritubular capillaritis, glomerulitis, and rapid decline in allograft function [4]. Prognostic markers of this complication are not well defined. We aimed to find out the demographic, histopathological and clinical characteristics of transplant recipients who developed AMR and to evaluate the impact of these features as well as antirejection treatment modalities on graft survival
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