Predictors of Embryo Fragmentation and Outcome Following Fragment Removal in IVF

Abstract

To assess predictors of embryo fragmentation in in vitro fertilization (IVF) as well as to compare cycle outcomes between low grade embryos subjected to defragmentation and high grade embryos not undergoing defragmentation. A retrospective, case-control trial We evaluated age, basal follicle stimulating hormone and estradiol levels, the number of retrieved oocytes and fertilization rates on 327 non-donor, fresh in vitro fertilization cycles. Outcome assessments following defragmentation included rates of implantation, clinical pregnancy, spontaneous abortion and live birth. Increased age and lower number of oocytes and embryos were associated with embryo fragmentation. Lower grade embryos after defragmentation yielded rates of implantation, clinical pregnancy, live birth, spontaneous abortion and fetal defects equivalent to high grade embryos Fragmented embryos that undergo fragment removal result in equivalent clinical outcomes to high grade, non-defragmented embryos.