Predictors of early diagnosis of obesity hypoventilation syndrome among patients with sleep disordered breathing

Abstract

BackgroundDetermine predictors of early diagnosis and prevalence of OHS among patient with sleep disordered breathing (SDB) at Mansoura SDB unit. Aim of workDetermine predictors of early diagnosis and prevalence of OHS among patient with sleep disordered breathing (SDB) diagnosed at Mansoura SDB unit. Patients and methodsThe study population consists of 212 patients referred to Mansoura University SDB unit for investigation of possible SDB. All patients were subjected to the following: Clinical evaluation, Pulse oximeter, Erect awake ABG, Spirometry and Polysomnography. ResultsIt was found that; The overall prevalence of OHS in studied cases was 13.2% (28 out of 212) and the prevalence of SDB in all studied cases was 83.02% (176 out of 212), 15.91% (28 out of 176) with OHS. The following predictors can be used for early diagnosis of OHS; a cutoff point of 93% of erect awake SpO2 with sensitivity of 97.1%, Specificity of 100%, p<0.001, a cutoff point of 28mmol/dL of serum HCO3 with sensitivity of 85.7%, specificity of 95.6%, p<0.001, and a cutoff point of 46.40 of AHI with sensitivity of 78.6%, specificity of 77.9 p=0.001. ConclusionThe prevalence of OHS among patients with SDB diagnosed at Mansoura SDB unit was 15.91% and 16.67% among obese patients with SDB. The following cutoff points can be used as promising predictors for early diagnosis of OHS: Erect awake SpO2<93%, Serum HCO3>28mmol/L and AHI>46.4.