Predictors of cognitive decline at 18 month follow up among 1112 participants in the Australian imaging, biomarkers and lifestyle flagship study of ageing (AIBL)

Abstract

factors influence the proportion of dementia subtypes. Dementia in India is expected to reach epidemic proportions in the next two decades but studies on dementia are few. We studied patients attending a memory clinic in a private hospital in South India to describe the clinical profile and compare the socio-cultural factors influencing diagnosis and dementia care in this population with studies from developed countries. Methods: Consecutive patients attending the memory clinic at Manipal hospital, Bangalore over three years were included. Socio-demographic information including income, education and linguistic background was collected. All patients underwent detailed neurological evaluation, cognitive testing, blood tests and neuroimaging. The diagnosis of MCI, dementia and the different subtypes was based on standard criteria. Results: The mean age at presentation was 65.8(9.0) years, range 4087 years. There were 127 men and 93 women. Of the total 220 patients, MCI was diagnosed in 57 (25.9%), Alzheimer’s disease (AD) in 62 (28.1%), vascular dementia (VaD) in 38 (17.3%), and mixed dementia in four patients. 37 (16.8%) patients were diagnosed as frontotemporal lobar degeneration (FTD) and its variants. Other degenerative dementias were seen in 13 and miscellaneous causes in 8 patients. One patient did not appear to have any cognitive impairment. Majority of the patients (80.4%) were bilingual or multilingual and 10 (4.9%) patients were illiterate. VaD was more common in men (3:1) and AD in women (1.5:1). Majority of the MCI patients had depression (54.4%) and seven patients developed AD during follow-up. All the patients were cared for at home by relatives except for one patient who had an appointed caretaker. Conclusions: Alzheimer’s disease was more common than vascular dementia in this study from an urban hospital in South India, in spite of the high prevalence of vascular risk factors in this population. Depression was a common cause of mild cognitive impairment. In this study of a relatively young (mean age) dementia cohort, all patients had home based care in contrast to studies from developed countries. P1-146 PREDICTORS OF COGNITIVE DECLINE AT 18 MONTH FOLLOW UPAMONG 1112 PARTICIPANTS IN THE AUSTRALIAN IMAGING, BIOMARKERS AND LIFESTYLE FLAGSHIP STUDY OFAGEING (AIBL) Kathryn A. Ellis, Christopher Rowe, ColinMasters, Cassandra Szoeke, Kevin Taddei, Ralph Martins, Victor Villemagne, Michael Fahey, David Ames, PaulMaruff, Ping Zhang, Greg Savage, AIBLResearch Group, Lance Macaulay, University of Melbourne, Kew; Austin Health, University of Melbourne, Heidelberg, Melbourne; University of Melbourne, Melbourne, VIC; CSIRO, Melbourne; Edith Cowan University, Perth; Edith Cowan University, Perth; Austin Health, Melbourne; Division of Mathematics, Informatics and Statistics, CSIRO, Parkville, VIC; National Ageing Research Institute, Parkville; CogState, Melbourne; CSIRO, Parkville; Macquarie Centre for Cognitive Science, Macquarie University, Sydney, NSW; Mental Health Research Institute, Perth; CSIRO, Parkville.