Predictors of Clinical Success After Surgery for Primary Aldosteronism in the Japanese Nationwide Cohort.

Abstract

ContextAldosterone-producing adenomas are a curable subtype of primary aldosteronism (PA); however, hypertension persists in some patients after adrenalectomy.ObjectiveTo identify factors associated with, and develop prediction models for, blood pressure (BP) normalization or improvement after adrenalectomy.DesignRetrospective analysis of patients treated between 2006 and 2018, with a 6-month follow-up.SettingA nationwide, 29-center Japanese registry encompassing 15 university hospitals and 14 city hospitals.PatientsWe categorized 574 participants in the Japan Primary Aldosteronism Study, who were diagnosed with PA and underwent adrenalectomy, as BP normalized or improved, on the basis of their presentations at 6 months postsurgery.Main Outcome MeasureThe rate of complete, partial, and absent clinical success. Predictive factors related to BP outcomes after PA surgery were also evaluated.ResultsComplete clinical success was achieved in 32.6% and partial clinical success was achieved in 53.0% of the patients at 6 months postsurgery. The following five variables were independent predictors for BP normalization: ≤7 years of hypertension, body mass index ≤25 kg/m2, no more than one antihypertensive medication, absence of medical history of diabetes, and female sex. The area under the receiver operator characteristic curve was 0.797 in the BP normalization model.ConclusionWe established models that predicted postoperative BP normalization in patients with PA. These should be useful for shared decision-making regarding adrenalectomy for PA.