PREDICTORS OF CHRONIC KIDNEY DISEASE DEVELOPMENT IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Abstract

Оbjective: to identify predictors of reduction of glomerular filtration in patients with chronic obstructive pulmonary disease (COPD). Materials and methods. Maps analyzed 145 patients with a diagnosis of COPD. The majority (84.1 %, n = 122) were male (the average age of men 60.7 ± 0.9 years, average age of women 62.0 ± 2.7 years). A comparative analysis of the prevalence of risk factors for chronic kidney diseace (CKD) in patients with COPD by age, sex, smoking, hypertension, overweight and others. Calculated glomerular filtration rate (GFR) by using the equation Chronic Kidney Disease Epidemiology Collaboration (CKD–EPI), according to which the patients were divided into 6 groups: group 1 – hyperfiltration, group 2 – GFRCKD–EPI ≥ 90 ml/min/1.73 m2 , group 3 – GFRCKD–EPI 60–89 ml/min/1.73 m2 , group 4 – GFRCKD–EPI 45–59 ml/min/1,73 m2 , group 5 – GFRCKD–EPI 30–44 ml/min/1,73 m2 and group 6 – GFRCKD–EPI < 30 ml/min/1.73 m2 . Results. In COPD patients there is a high frequency of risk factors for CKD. The correlation between the prevalence of risk factors for CKD and the severity of COPD. The main predictors of CKD in patients with COPD: COPD experience more than 9.0 years, body mass index more than 26.5 kg/m2 , smoker index more of 51.3, albumin 44.0 g/l, total protein of more than 70.0 g/l, forced expiratory volume in the first second of less than 1.6 l, right atrium more than 35.5 mm, systolic pulmonary artery pressure more than 36.6 mm Hg, the thickness of the posterior wall of the left ventricle more than 10.5 mm, the Tiffeneau index less than 62.0 %. Conclusion. It is established that in COPD patients there is a high frequency of both traditional and additional risk factors for reduced GFR.