Predictors of Bronchopulmonary Dysplasia (BPD) in a Low BPD Setting:A 6-Year Population-Based Cohort of the Marche Region

Abstract

Background and Objective: BPD remains a severe complication of premature birth. We studied the risk factors and early predictors of BPD.Methods: All infants from 24,0 to 31,6 weeks born in the Marche Region from 2004 to 2009 were studied.Results: 629 infants were eligible, with 69 deaths (11%), 97 BPDs (15.4%),161 deaths and/or BPD (25.6%). Histological chorioamnionitis (HCA) were 12,3% and culture proven sepsis 13.7%. Gestational age(GA), birth weight (BW),BW standard deviation score (BW-SDS),duration of mechanical ventilation and continuous positive airway pressure, oxygen supplementation, intubation within 6 hours from birth, ventilation associated pneumonia, patent ductus arteriosus (PDA), sepsis, respiratory distress syndrome (RDS), surfactant treatment (number of doses, age at 1stdose, oxygenation-index (OI) and FiO2 before the 1stdose), pulmonary hypertension, inhaled nitric oxide (iNO), were all significant at the univariate analysis. We found no significant association between BPD and HCA or early-onset sepsis. Multivariate logistic regression analysis is reported in table below. Table Table Full size table Conclusion: In our cohort of preterm infants receiving “optimal” prenatal care with a low rate of complications, BPD percentage was low and significantly associated with RDS severity and PDA but not with sepsis and/or HCA.