Abstract
Information regarding the outcomes of transcatheter aortic valve replacement (TAVR) in men is limited. This study aimed to investigate short- to mid-term outcomes and prognostic predictors in this population. The data of 519 men were analyzed from 1,693 consecutive patients with symptomatic severe aortic stenosis who underwent TAVR at six hospitals between April 2010 and July 2020. The primary endpoint was all-cause mortality at 30days after TAVR. The mean age and Society of Thoracic Surgeons (STS) score were 83.7±5.9years and 6.3±4.7%, respectively. Overall, 23.5% of patients consumed alcohol with a frequency of>1 drinks/week, and 12.1% consumed alcohol with a frequency of>8 drinks/week, while 66.1% were former smokers and 4.2% were current smokers. Mortality at 30days was 0.8%. During the median follow-up period of 448days, the estimated survival rates at 1year post-TAVR was 90.7±1.4%. In multivariate analysis, the serum albumin level [hazard ratio (HR): 2.20, 95% confidence interval (CI):1.36-3.62, p=0.001], atrial fibrillation (HR: 1.79, 95% CI: 1.13-2.82, p=0.012), and STS score (HR: 1.33, 95% CI: 1.06-1.67, p=0.015) were independently associated with all-cause mortality following TAVR. Adjusted hazard ratios of current smoking, heavy drinking, and presence of cancer were 1.05 (95% CI: 0.36-2.98),1.37 (95% CI: 0.75-2.48), and 1.13 (95% CI: 0.75-2.48), respectively. Our study demonstrated that serum albumin levels, atrial fibrillation, and STS score were independently associated with all-cause mortality following TAVR in men.
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More From: International journal of cardiology. Heart & vasculature
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