Predictivity of Platelet to Lymphocyte and Neutrophil to Lymphocyte Ratios in the First Trimester Missed Abortion:A Retrospective Case-Control Study

Abstract

Objective: The aim of the study is to investigate the predictive value of neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in predicting the outcome of missed abortion (MA). Material and Methods: In this retrospective case-control study, 50 MA patients and 50 matched healthy pregnant women admitted to our clinic, between January 2018 and November 2021, were included. The preoperative complete blood count parameter of the MA and control group, which were evaluated at the week of gestation in the fetal heart rate was detected in the first trimester were compared. The receiver operating characteristic (ROC) curve was used to calculate the predictive values. Results: PLR was higher in the MA group, but this value was not statistically significant (p=0.3). NLR was higher in the MA group and there was a significant difference between the groups (p=0.02). The multivariate analysis also revealed that NLR was the prognostic factor of MA (p=0.04). ROC analysis showed that the best predictive values for MA based on the area under the curve (AUC) was NLR with the optimal cutoff value of 4.56, and the AUC was 0.62, the specificity and sensitivity were 52% and 86% respectively (p=0.02). Conclusion: NLR is a suitable predictor of MA in the first trimester. The results of the study may help predict a defective placentation and inflammation in the pathogenesis of MA.