Abstract
Aim: This study aimed to test the predictive power of serum uric acid (UA) levels on new-onset cardiometabolic risk in the Chinese population.Methods: Older people who visited a community health center for a yearly health check (N = 5,000; men: 47%, women: 53%) were enrolled. Participants were followed for 4 years from baseline (median: 48 months), with the endpoints being development of heart failure, atrial fibrillation, diabetes, hypertension, metabolic syndrome, or kidney disease.Results: During follow-up, 342 men (7.4%) and 360 women (8.6%) developed hypertension; 98 men (2.48%) and 135 women (3.06%) developed diabetes; and 175 men (5.04%) and 214 women (4.51%) developed metabolic syndrome. Incident diabetes, hypertension, and metabolic syndrome increased with increased UA levels at baseline (P < 0.001). A multivariate Cox proportional hazards analysis revealed a significant, independent association between the baseline UA level and the onset and future hypertension and/or diabetes in both men and women. However, UA is associated with the development of metabolic syndrome in men, but not in women.Conclusion: UA is an independent predictor of new-onset diabetes and hypertension in both women and men and a predictor of new-onset metabolic syndrome only in men.
Highlights
Lifestyle changes have been shown to be a significant factor in the increasing prevalence of hyperuricemia, and several studies have indicated that uric acid (UA) is a risk factor for cardiometabolic disease in clinical settings [1,2,3,4,5]
In the analysis of variance (ANOVA) analysis, age and diastolic BP were not significantly associated with the increasing levels of serum UA in men, and total cholesterol (TC) and glucose were not significantly associated with the increasing levels of UA in women
Age and diastolic BP were not included in the Cox regression analysis for men and TC and glucose were not included in that for women
Summary
Lifestyle changes have been shown to be a significant factor in the increasing prevalence of hyperuricemia, and several studies have indicated that uric acid (UA) is a risk factor for cardiometabolic disease (e.g., hypertension, diabetes mellitus, chronic kidney disease, coronary heart disease or stroke) in clinical settings [1,2,3,4,5]. It is well-established that older people are at increased risk of cardiometabolic disease [7, 8]. Previous studies have shown that high UA levels are associated with hypertension. This studies have not comprehensively assessed the association between hyperuricemia and cardiometabolic disease, including stroke, coronary disease, and cardiovascular events.
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