Abstract
before injection, no differences in colony numbers were shown. These results suggest that different AML progenitor cells can be defined in the whole AML population, dependent on the test system used. Moreover, the findings indicate a hierarchy in AML progenitors, including cells with short-term and longterm repopulating abilities, as has already been defined in the normal counterpart. This expanding knowledge on the biological behaviour of AML progenitors ita vitro may be used in future clinical trials to optimise new therapeutic strategies, especially in the possible elimination of AML progenitor cells from the graft.
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