Abstract
Introduction. One of the urgent tasks in modern transplantology is the search of biomarkers for predicting and early diagnosis of graft dysfunction.Objective. The study objective was to determine the biomarkers of liver graft dysfunction.Material and methods. We have examined 19 recipients who underwent liver transplantation and 36 healthy blood donors. Levels of 7 serum cytokines were measured by multiparametric fluorescence analysis with magnetic microspheres (xMAP technology, Luminex 200, USA). Statistical analysis was carried out by methods of nonparametric statistics. To determine the predictive value of the test, a ROC-analysis was performed.Results and discussion. We found that the interleukin-8 level was 3.6 times higher in recipients with liver graft dysfunction compared to those who had an uneventful postoperative course. The diagnostic sensitivity of the test was 75%, the specificity was 91%, and negative predictive value was 84.6.Conclusion. Serum interleukin-8 measurement provides a biomarker for early predicting a post-transplant liver graft dysfunction development
Highlights
One of the urgent tasks in modern transplantology is the search of biomarkers for predicting and early diagnosis of graft dysfunction
The study objective was to determine the biomarkers of liver graft dysfunction
We have examined 19 recipients who underwent liver transplantation and 36 healthy blood donors
Summary
Одной из актуальных задач современной трансплантологии является поиск биомаркеров для прогнозирования и ранней диагностики дисфункции трансплантата печени. Обследованы 19 реципиентов печеночного трансплантата и 36 условно здоровых доноров крови. Всем обследованным проводили измерение уровня 7 сывороточных цитокинов методом мультипараметрического флуоресцентного анализа с магнитными микросферами (технология xMAP, Luminex 200, USA). Для определения прогностической значимости теста проводили ROC-анализ. Что уровень интерлейкина-8 был в 3.6 раз выше у реципиентов с дисфункцией трансплантата по сравнению с теми у кого послеоперационный период протекал без осложнений. Диагностическая чувствительность теста составила 75%, специфичность – 91%, а прогностическая ценность отрицательного результата теста – 84,6. Измерение уровня сывороточного интерлейкина-8 является биомаркером раннего прогнозирования развития дисфункции трансплантата печени после трансплантации
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