Predictive value of preoperative inflammatory response biomarkers for metabolic syndrome and post-PCNL systemic inflammatory response syndrome in patients with nephrolithiasis

Kun Tang,Tao Ye,Hua Xu,Haoran Liu,Zhiqiang Chen,Kehua Jiang,Ding Xia,Peijun Liu,Zhangqun Ye,Libin Yan

doi:10.18632/oncotarget.20344

Abstract

Neutrophil to lymphocyte ratio (NLR), derived neutrophil to lymphocyte ratio (dNLR), platelet to lymphocyte ratio (PLR) and lymphocyte to monocyte ratio (LMR) were promising biomarkers used to predict diagnosis and prognosis in various inflammatory responses diseases and cancers. However, there have been no reports regarding these biomarkers in kidney stone patients. This study aimed to evaluate the predictive value of inflammatory biomarkers for metabolic syndrome (MetS) and post-PCNL SIRS in nephrolithiasis patients. We retrospectively enrolled 513 patients with nephrolithiasis and 204 healthy controls. NLR, dNLR, LMR and PLR in nephrolithiasis patients were significantly higher than control group. Patients with renal stone have higher NLR, dNLR, LMR and PLR than those without. ROC curve analysis indicated NLR, dNLR, LMR and PLR for predicting patients with nephrolithiasis and MetS, displayed AUC of 0.730, 0.717, 0.627 and 0.606. Additionally, ROC curves, using post-PCNL SIRS as the end-point for NLR, dNLR, LMR and PLR with AUC of 0.831, 0.813, 0.723 and 0.685. Multivariate analysis revealed that NLR, dNLR represented independent factors for predicting post-PCNL SIRS. While LMR independently associated with MetS. These resluts demonstrate preoperative NLR, dNLR and LMR appears to be effective predictors of post-PCNL SIRS and LMR of MetS in nephrolithiasis patients.

Highlights

Nephrolithiasis is an increasingly common condition in the Asia with a prevalence of 10.6% and 7.1% in men and women, respectively, [1] causing a heavy economic burden
This study aimed to evaluate the predictive value of inflammatory biomarkers for metabolic syndrome (MetS) and postPCNL systemic inflammatory response syndrome (SIRS) in nephrolithiasis patients
We demonstrated that increased pre-operation Neutrophil to lymphocyte ratio (NLR), www.impactjournals.com/oncotarget derived neutrophil to lymphocyte ratio (dNLR), lymphocyte to monocyte ratio (LMR) and platelet to lymphocyte ratio (PLR) positively correlated with MetS comorbidities and post-Percutaneous nephrolithotomy (PCNL) SIRS in patients with kidney stones

Summary

Introduction

Nephrolithiasis is an increasingly common condition in the Asia with a prevalence of 10.6% and 7.1% in men and women, respectively, [1] causing a heavy economic burden. Several circulating blood cell-based biomarkers including: neutrophil to lymphocyte ratio (NLR), derived neutrophil to lymphocyte ratio (dNLR), [3] platelet to lymphocyte ratio (PLR) and lymphocyte to monocyte ratio (LMR) were used to predict diagnosis and prognosis in various diseases. These markers can be readily calculated from www.impactjournals.com/oncotarget routine complete blood counts from peripheral blood specimens in the clinical practice. They are routinely measured and inexpensive to test, and potentially provide readily available objective information to help doctors to estimate patient progression

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