Abstract
Objective: To determine the predictive value of high-sensitive C-reactive protein (hs-CRP)/albumin ratio in systemic inflammatory response syndrome (SIRS) after semi-rigid ureteroscopy (URS).Material and Methods: Between April 2021 and October 2021, 148 patients who had ureteral stone treatment with a ureteroscope in our hospital were included. Preoperative hs-CRP/albumin ratio was obtained by dividing the hs-CRP level by the albumin level. High-sensitivity modified Glasgow prognostic score (hs-mGPS) was obtained according to hs-CRP and albumin values. Two groups were identified as post-URS SIRS positive and negative. Inflammation biomarkers were evaluated in groups.Results: There was a statistically significant difference between groups in terms of preoperative hs-CRP, albumin, and hs-CRP/albumin ratio (p < 0.001, p = 0.003, and p < 0.001, respectively). The optimal cutoff value for the hs-CRP/albumin ratio was 0.04651. While the risk of developing SIRS after surgery was 72.73% in patients with a hs-CRP/albumin ratio higher than 0.04651, the chance of not developing SIRS was 87.5% in patients below this value. The probability of developing SIRS was found to be significantly different in hs-mGPS (p < 0.001).Conclusion: Our study indicated that hs-CRP/albumin ratio can predict post-URS SIRS. Larger-scale, multicentric prospective studies should certainly be done to validate the predictive value of hs-CRP/albumin ratio in post-URS SIRS.
Highlights
Semi-rigid ureteroscopy (URS) is a method recommended in current urology guidelines in the treatment of ureteral stones [1]
The probability of developing systemic inflammatory response syndrome (SIRS) was found to be significantly different in High-sensitivity modified Glasgow prognostic score (hsmGPS) (p < 0.001)
Our study indicated that high-sensitive C-reactive protein (hs-CRP)/albumin ratio can predict post-URS SIRS
Summary
Semi-rigid ureteroscopy (URS) is a method recommended in current urology guidelines in the treatment of ureteral stones [1]. The rate of infectious complications after URS is 9%-25% [3]. It is of great importance to predict infectious complications after URS. The predictive value of these markers for postoperative systemic inflammatory response syndrome (SIRS) after kidney stone surgery was shown in some studies. High-sensitive C-reactive protein (hsCRP)/albumin ratio is a novel inflammation marker. Studies indicating the predictive value of the hsCRP/albumin ratio in SIRS after endoscopic stone surgery are limited. The high-sensitivity modified Glasgow prognostic score (hs-mGPS), obtained according to hs-CRP and albumin levels, is a new systemic inflammation biomarker that provides sensitive measurements due to the use of lower threshold values. The predictive value of hsCRP/albumin in post-PNL SIRS has been demonstrated [8]. Our purpose is to determine the predictive value of hsCRP/albumin ratio in post-URS SIRS
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