Predictive value of phosphorylated neuro-filament h as a marker of brain injury after cardiac arrest

S El Maraghi,M El Saied,N Samir,H Saber

doi:10.1186/2197-425x-3-s1-a203

S El Maraghi, M El Saied + Show 2 more

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https://doi.org/10.1186/2197-425x-3-s1-a203

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Abstract

Highlights

Intr Anoxic brain insult is a sequalae of tissue hypoperfusion during cardiac arrest that may lead to varieties of neurological outcome in patients [1].One of the main drawbacks in the diagnosis of brain injury post-cardiac arrest is the absence of a widely available and rapid diagnostic test. pNFH might be an ideal biomarker for brain injury as it is axon specific [2],highly immunogenic [3] and an excellent target for antibody-based assays [4]
The cut off level of pNF-H to detect severe disability and death was 0.201 ng/ ml on day 1 with sensitivity 85% and specificity 70% with a p-value 0.022
A total of 30 critically ill patients admitted to the critical care departments of Cairo and Beni Suef Universities and had cardiac arrest during their ICU stay were prospectively studied

Summary

Introduction

Intr Anoxic brain insult is a sequalae of tissue hypoperfusion during cardiac arrest that may lead to varieties of neurological outcome in patients [1].One of the main drawbacks in the diagnosis of brain injury post-cardiac arrest is the absence of a widely available and rapid diagnostic test. pNFH might be an ideal biomarker for brain injury as it is axon specific [2],highly immunogenic [3] and an excellent target for antibody-based assays [4]. Correlation between pNFH and Rankin score on day 3 with r value = 0.814 & P value > 0.001. Patients with higher levels of pNFH on day 1 post arrest and on day 3 showed a greater CPC score liable for severe disability and poor outcome (CPC = 3,4,5), (r = 0.52, p = 0.003) and (r = 0.84, p < 0.001) respectively.

Results

Conclusion