Abstract
Objectives:This study was conducted to evaluate the diagnostic value of platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) in vaginitis patients.Methods:This cross-sectional retrospective study was performed in Afyon Dinar State Hospital between July 2016 to August 2017. A total of 64 bacterial vaginosis (BV) patients, 66 vulvovaginal candidiasis (VVC) patients and 65 age-matched control subjects were enrolled. NLR, PLR, mean platelet volume (MPV), red cell distribution width (RDW) and other conventional inflammatory marker values were recorded for all patients before and after treatment.Results:In the BV group, NLR values were found to be elevated compared to VVC and healthy controls [2.9 (1.2-14.7), 2.1 (1.1-11.7) and 2.1 (0.8-7.0), respectively] (p=0.008). Although not found to be statistically significant, the median NLR levels of BV patients decreased from 2.9 (1.2-14.7) to 2.4 (1.2-7.0) after treatment. PLR levels did not show a statistically significant difference between the three groups (p=0.970). The cut-off value of the NLR for BV was 2.19, with 67.2% sensitivity and 63.8% specificity.Conclusions:The present study demonstrated that NLR levels are elevated in bacterial vaginosis and NLR levels can be used as a reflection of systemic inflammatory response in vaginosis patients.
Highlights
Vaginitis either bacterial or fungal origin is one of the commonest reproductive tract infections amongst sexually active women and characterized with inflammation of the vagina as a result of infectious agents
The study consisted of 64 patients with bacterial vaginosis (BV), 66 patients with vulvovaginal candidiasis (VVC), and 65 healthy controls with a mean age of 33.3±9.9, 32.7±10.3 and 31.2±10.2 (Table-I)
No statistically significant differences in hemoglobin, platelet, mean platelet volume (MPV), platelet distribution width (PDW), red cell distribution width (RDW), and platelet-to-lymphocyte ratio (PLR) were observed between groups (p>0.05) (Table-I)
Summary
Vaginitis either bacterial or fungal origin is one of the commonest reproductive tract infections amongst sexually active women and characterized with inflammation of the vagina as a result of infectious agents. It usually presents with vaginal discharge, vulvar itching, irritation, odour and dysuria. The most common etiologic agents of infectious vaginitis are bacterial vaginosis (BV), candidiasis and trichomoniasis, which generally account for 90% of all etiologies.[1] clinical differentiation of various forms of infectious vaginitis is unreliable, there are certain individual symptoms and signs that are associated with the disease.
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