Predictive Value of Myocardial injury in Patients with COVID-19 Admitted to a Quaternary Hospital in the City of Rio de Janeiro

Antônio Sérgio Cordeiro Da Rocha,Alexandre Siciliano Colafranceschi,Andre Volschan,Roberta Pereira Dos Santos Coelho,Dominique Cardoso De Almeida Thielmann,Carlos Augusto Lobbe Cotta Ferreira,Luiz Antonio Almeida Campos

doi:10.36660/ijcs.20200352

Antônio Sérgio Cordeiro Da Rocha, Alexandre Siciliano Colafranceschi + Show 5 more

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https://doi.org/10.36660/ijcs.20200352

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Abstract

Background In Brazil the factors involved in the risk of death in patients with COVID-19 have not been well established. Objective To analyze whether elevations of high-sensitivity troponin I (hTnI) levels influence the mortality of patients with COVID-19. Methods Clinical and laboratory characteristics of hospitalized patients with COVID-19 were collected upon hospital admission. Univariate and binary logistic regression analyzes were performed to assess the factors that influence mortality. P-value50% in chest computed tomography (P=0.011), with previous coronary artery disease [...]

Highlights

Since the first reported cases in Wuhan, China, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread rapidly worldwide
SARS-CoV-2 explicitly refers to an aggression in the lungs, often inducing acute respiratory distress syndrome (ARDS), it affects other organs, including blood vessels, brain, gastrointestinal tract, kidneys, heart, and liver,[2] and cardiovascular complications are manifestations that contribute significantly to the mortality of these patients.[3]
This study sought to verify whether the elevation of high-sensitive troponin I levels upon hospital admission is an independent predictive factor of higher mortality in hospitalized patients with COVID-19. This retrospective study involved a cohort of patients over 18 years of age who received hospital admission between March 16 and June 2, 2020, with a diagnosis of COVID-19, confirmed by nasopharyngeal reverse transcription-polymerase chain reaction (RT-PCR), or IgM and IgG measurement by chemiluminescent microplate immunoassay technique, and who were discharged or died by July 2, 2020

Summary

Introduction

Since the first reported cases in Wuhan, China, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread rapidly worldwide. Several biomarkers of myocardial injury are elevated in patients with COVID-19, and a rise in troponin levels. Objective: To analyze whether elevations of high-sensitivity troponin I (hTnI) levels influence the mortality of patients with COVID-19. Results: This study analyzed[192] patients who received hospital admission between March 16 and June 2, 2020 and who were discharged or died by July 2, 2020. More patients, aged≥60years (P 1 (P=0.004), lung injury>50% in chest computed tomography (P=0.011), with previous coronary artery disease (P=0.037), hypertension (P=0.033), stroke (P=0.008), heart failure (P=0.002), lymphocytopenia (P=0.024), high D-dimer (P=0.024), high INR (P=0.003), hTnI (P

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