Predictive value of Lipocalin 2 and hyperuricemia on maternal and fetal outcome in pre-eclampsia

Abstract

Background: Pre-eclampsia is a complex hypertensive syndrome that originates in early pregnancy and leads to considerable maternal and fetal morbidity and mortality. Lipocalin 2 is low in healthy human tissue but increased in pathological conditions following endothelial cell injury. Women with pre-eclampsia showed elevated uric acid level in the maternal blood.Objective: To assess the predictive value of Lipcalin 2 and hyperuricemia on the severity of pre-eclampsia and on maternal and fetal outcome.Patients and Methods: Sixty women enrolled in the present study were forty affected by preeclampsia and 20 women with uncomplicated pregnancies formed the control group. All women included in the study were subjected to; complete history taking; clinical and blood pressure evaluation; measurements of biochemical parameters and evaluation of maternal and fetal well-being.Results: Thirty-two of hypertensive women were mild pre-eclampsia having blood pressure ≥140/90mmHg but less than 160/110mmHg. Eight cases were severe pre-eclampsia with the presence of blood pressure ≥160/110 mmHg. All hypertensive women showed statistically significant increased biochemical parameters compared to control p<0.001. Lipocalin 2 and serum uric acid levels in the studied group showed a positive correlation with various biochemical parameters and hyperuricaemia showed a good relation with the pathogenesis of the maternal and fetal manifestations.Conclusion: Lipocalin 2 could be used as a sensitive indicator of severity of preeclampsia. On the other hand hyperuricaemia showed a good relationship with fetal outcome in hypertensive disorder of pregnancy, identifying those fetuses that are likely to have Intra Uterine Growth Retardation and high perinatal mortality.