Predictive value of general movements' quality in low-risk infants for minor neurological dysfunction and behavioural problems at preschool age

Abstract

BackgroundGeneral movement (GM) assessment is a well-established tool to predict cerebral palsy in high-risk infants. Little is known on the predictive value of GM assessment in low-risk populations. AimsTo assess the predictive value of GM quality in early infancy for the development of the clinically relevant form of minor neurological dysfunction (complex MND) and behavioral problems at preschool age. Study designProspective cohort study. SubjectsA total of 216 members of the prospective Groningen Assisted Reproductive Techniques (ART) cohort study were included in this study. ART did not affect neurodevelopmental outcome of these relatively low-risk infants born to subfertile parents. Outcome measuresGM quality was determined at 2weeks and 3months. At 18months and 4years, the Hempel neurological examination was used to assess MND. At 4years, parents completed the Child Behavior Checklist; this resulted in the total problem score (TPS), internalizing problem score (IPS), and externalizing problem score (EPS). Predictive values of definitely (DA) and mildly (MA) abnormal GMs were calculated. ResultsDA GMs at 2weeks were associated with complex MND at 18months and atypical TPS and IPS at 4years (all p<0.05). Sensitivity and positive predictive value of DA GMs at 2weeks were rather low (13%–60%); specificity and negative predictive value were excellent (92%–99%). DA GMs at 3months occurred too infrequently to calculate prediction. MA GMs were not associated with outcome. ConclusionsGM quality as a single predictor for complex MND and behavioral problems at preschool age has limited clinical value in children at low risk for developmental disorders.