Predictive value of fasting plasma glucose and body mass index of pre-pregnancy women for gestational diabetes mellitus

Abstract

To analyze the relationship between fasting plasma glucose (FPG) and body mass index (BMI) of pre-pregnancy women and the occurrence of gestational diabetes mellitus(GDM), and to explore a effective method for GDM screening. This was a retrospective clinical study including the pregnant women who underwent screening for GDM recently and also participated in national free preconception health examination at three medical centers. They were divided into normal group and GDM group base on the 2011 diagnosis criteria for GDM of our country. FPG, BMI and diastolic blood pressure before pregnancy in GDM group were significantly higher than those in normal group (P<0.01). Multiple logistic-regression showed that the women with higher FPG and BMI level before pregnancy had higher risk of diagnosis of GDM. The receiver operating characteristic (ROC) curves showed that the area under the curve (AUC) were 0.600 and 0.632 for FPG and BMI, respectively, in predicting GDM (P<0.01). The FPG and BMI level of women before pregnancy are valuable predictors for early diagnosis of GDM.