Abstract
Background: This study explored the predictive value of postoperative C-reactive protein in children with hypospadias for postoperative complications and the risk factors.Methods: The clinical and follow-up data of 106 children with hypospadias who were treated with operations at Kunming Children's Hospital in 2020 were, respectively, analyzed. According to the occurrence of postoperative complications, the patients were divided into two groups: 25 patients with postoperative complications were the complications group, and 81 without postoperative complications were the control group. The baseline data, clinical characteristics, laboratory test indexes, and outcome of the two groups were collected. Receiver operating characteristic (ROC) was used to calculate the optimal cutoff value of C-reaction protein (CRP). Logistic regression was used to analyze the risk factors of hypospadias after surgery. A probability value (P) < 0.05 was considered statistically significant.Results: According to the result of the ROC curve, the optimal cutoff value of CRP was 11.7 mg/L. Logistic regression showed that the length of urethral defect, the urethral material, the operative produce, and the postoperative CRP level were related to the occurrence of postoperative complications of patients with DCC. The length of the urethral defect and the CRP level were the independent risk factors of the prognosis of hypospadias patients. The CRP level was related to the occurrence of postoperative complications and fistula.Conclusions: Postoperative CRP level can be used as a reliable marker for predicting the prognosis of hypospadias patients.
Highlights
This study explored the predictive value of postoperative C-reactive protein in children with hypospadias for postoperative complications and the risk factors
Heredity and gene mutations are C-reactive protein (CRP) Affects the Prognosis of Hypospadias common causes of hypospadias, and mutations of androgen receptor, Wilms tumor protein-1, steroid-α reductase, and other genes are closely related to the occurrence of hypospadias
Long-term followup studies have found that adults with hypospadias may have abnormal urethral function, unsatisfactory appearance of the penis, and problems with erection, ejaculation, or sexual intercourse, which often negatively affect their quality of life [9]
Summary
This study explored the predictive value of postoperative C-reactive protein in children with hypospadias for postoperative complications and the risk factors. Hypospadias is a common congenital malformation in male individuals, which is mainly manifested by an abnormal ventral opening of the urethral meatus, abnormal distribution of foreskin, and chordee. The incidence of hypospadias is about 1/300–1/250 [1, 2]. In the past 30 years, the incidence of hypospadias has been on the rise [3, 4]. Long-term followup studies have found that adults with hypospadias may have abnormal urethral function, unsatisfactory appearance of the penis, and problems with erection, ejaculation, or sexual intercourse, which often negatively affect their quality of life [9]. Many people with hypospadias need psychological treatment as adults. Improving the operative success rate is the key to cure genitalia malformations and meet the cosmetic needs of patients
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
