Predictive value of C-reactive protein, D-dimer, Hemoglobin and Lactate dehydrogenase levels in diagnosing COVID-19 patients

Abstract

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused enormous issues worldwide and is the most infectious pandemic. 50 subjects (evenly distributed between sexes) were included in this study, as well as their range of ages starting from 2 to 67 years. According to the study's result, the age and gender of the subjects include susceptibility to COVID-19; males were found to be more infected than females, and the ages 36 to 67 were more common than in other age ranges. Also, BMI calculations revealed that male patients with COVID-19 had the highest percentage of obesity. The clinical parameter results have been found serum C‐reactive protein (CRP) as an essential indicator that changes significantly in infection with COVID‐19 and inflammation. The concentration of CRP is higher levels for positive COVID‐19 patients (male and female) with mild symptoms of COVID-19 than those with negative COVID‐19 infection, and CRP levels were found to be higher in male than female patients. The results of D-dimer levels determined a nonsignificant difference in D-dimer levels in COVID-19 patients and non-COVID-19 patients than the normal concentration (N: Less than 500mg/dl.). The results of hemoglobin blood levels demonstrated significant variations between COVID-19 patients and non-COVID-19 patients and a decrease in Hb concentration compared to normal concentration (N: 11-16 g/dl.); thus, a link between anemia and inflammation. The lactate dehydrogenase (LDH) levels increased in positive COVID-19 patients male were (178.79 ± 56.08) mg/dl, and positive COVID-19 patients female were (141.57 ± 46.90) mg/dl than normal (N: Less than100mg/dl.), and significant variation was observed between positive and negative COVID-19 patients. Keywords: COVID-19; C‐reactive protein; hemoglobin; lactate dehydrogenase.