Abstract
BackgroundElevated CRP and increased CCA-IMT are both associated with the occurrence of stroke. CRP and IMT are closely associated; the higher the CRP, the greater the carotid atherosclerosis as measured by carotid IMT.ObjectivesTo study the relationship between elevated C-reactive protein as a blood biomarker and increased intimal media thickness of carotid artery, and its relation to infarct size and its impact on prognosis.Materials and methodsThis study is an analytical observational study, in which 73 patients who have recently suffered first-ever acute ischemic stroke in the anterior circulation within 72 h were recruited. Only 64 of them were able to continue the study with follow-up during the 1 month and 3 months durations. Magnetic resonance imaging for the brain was done and the infarct volume was measured. All patients had quantitative Serum CRP level within 72 h from stroke onset and carotid duplex with assessment of carotid intimal media thickness (IMT).ResultsThe results showed there is a significant positive correlation between highly sensitive C-reactive protein (hs-CRP) and MRS after 1 month yet no significant correlation was found between hs-CRP and IMT.ConclusionHighly sensitive C-reactive protein (hs-CRP) could serve as prognostic blood biomarker in long-term follow-up of stroke patients. Non-significant correlation was found in our study between increased hs-CRP and increased intima-media thickness (CCA-IMT).
Highlights
Increased intima-media thickness is considered the earliest sign of carotid atherosclerosis
The results showed there is a significant positive correlation between highly sensitive C-reactive protein and MRS after 1 month yet no significant correlation was found between hs-CRP and intimal media thickness (IMT)
Non-significant correlation was found in our study between increased hs-CRP and increased intima-media thickness (CCA-IMT)
Summary
Increased intima-media thickness is considered the earliest sign of carotid atherosclerosis. IMT is measured on the far wall of distal common carotid arteries (CCA). There is an association between brain infarction (BI) and common carotid arteries-intima media thickness (CCAIMT); this association was present in the main BI subtypes [1]. As a reflector of systemic atherosclerosis, increased carotid artery IMT of circulating markers of inflammation as potential predictors of the presence of cardiovascular disease (CVD) and the risk of future CVD events. The ability of hs-CRP to predict CVD risk is independent of the effects of traditional risk factors. Without direct threat to the brain, has been linked to an elevated risk for stroke. Elevated CRP and increased CCA-IMT are both associated with the occurrence of stroke. CRP and IMT are closely associated; the higher the CRP, the greater the carotid atherosclerosis as measured by carotid IMT
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