Abstract
BackgroundPsoriasis is a multisystem inflammatory disorder with variable morphology, clinical pattern and multiple comorbidities. Interplay between genetic and environmental factors leading to an aberrant immune response in the skin may contribute to disease development. The assessment for risk factors, signs, and symptoms of potential comorbid diseases is an important component of patient management. The aim of this study is to determine rheumatoid factors (RF) positivity and its levels in psoriasis patients, and describe its relationship with the demographic and clinical characteristics, comorbidities, and disease patterns of psoriasis.ResultsRheumatoid factor was positive in psoriatic patients more than control,30% of patients had positive rheumatoid factor while only 10% of control had positive results. Rheumatoid factor level was 63.8 ± 186.7 IU/ml in psoriasis vs. 9.3 ± 12.3 in control. Thirty percent of psoriasis patients have positive rheumatoid factor vs. 10% of control. There was no significant statistical difference between psoriasis patients with or without arthritis as regard rheumatoid factor positivity and titer; rheumatoid factor was positive in 20% in psoriatic patients with arthritis vs. 26% in psoriatic patients without arthritis. In psoriatic patients, the status of rheumatoid factor did not relate to disease severity, onset, course, site of affection, presence of scalp, nail affection, and presence of dactylitis (p value>0.5).ConclusionPsoriasis was associated with higher seropositivity of RF compared to age-matched non-psoriatic healthy controls. Occurrence and level of rheumatoid factor were not associated with severity or clinical pattern of psoriasis.
Highlights
Psoriasis is a multisystem inflammatory disorder with variable morphology, clinical pattern and multiple comorbidities
Rheumatoid factors (RFs) are antibodies against the Fc portion of immunoglobulin G (IgG), they gain their name because of their first detection in Rheumatoid arthritis (RA) patients, rheumatoid factors (RF) are found in patients with other autoimmune and non-immune diseases, as well as-in healthy people
There was no significant difference between patients and control as regards age, gender, and presence of comorbidities
Summary
Psoriasis is a multisystem inflammatory disorder with variable morphology, clinical pattern and multiple comorbidities. The aim of this study is to determine rheumatoid factors (RF) positivity and its levels in psoriasis patients, and describe its relationship with the demographic and clinical characteristics, comorbidities, and disease patterns of psoriasis. RF is not routinely detected in the absence of an antigenic stimulus; as direct infection by virus, chronic antigenic stimulation by immune complexes [1, 2]. There is evidence that RF may promote pathological inflammatory cytokine production through interactions with anti-citrullinated peptide antibodies (ACPA) immune complexes in rheumatoid arthritis. Possible beneficial functions include processing of antigens in immune complexes, Presentation of antigens to T lymphocytes, Immune tolerance, amplification of the humoral response to infection and Immune complex clearance [3,4,5].
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