Abstract
BackgroundDynamic arterial elastance (Eadyn) has been extensively considered as a functional parameter of arterial load. However, conflicting evidence has been obtained on the ability of Eadyn to predict mean arterial pressure (MAP) changes after fluid expansion. This meta-analysis sought to assess the predictive performance of Eadyn for the MAP response to fluid expansion in mechanically ventilated hypotensive patients.MethodsWe systematically searched electronic databases through November 28, 2020, to retrieve studies that evaluated the association between Eadyn and fluid expansion-induced MAP increases in mechanically ventilated hypotensive adults. Given the diverse threshold value of Eadyn among the studies, we only reported the area under the hierarchical summary receiver operating characteristic curve (AUHSROC) as the primary measure of diagnostic accuracy.ResultsEight observational studies that included 323 patients with 361 fluid expansions met the eligibility criteria. The results showed that Eadyn was a good predictor of MAP increases in response to fluid expansion, with an AUHSROC of 0.92 [95% confidence interval (CI) 0.89 to 0.94]. Six studies reported the cut-off value of Eadyn, which ranged from 0.65 to 0.89. The cut-off value of Eadyn was nearly conically symmetrical, most data were centred between 0.7 and 0.8, and the mean and median values were 0.77 and 0.75, respectively. The subgroup analyses indicated that the AUHSROC was slightly higher in the intensive care unit (ICU) patients (0.96; 95% CI 0.94 to 0.98) but lower in the surgical patients in the operating room (0.72; 95% CI 0.67 to 0.75). The results indicated that the fluid type and measurement technique might not affect the diagnostic accuracy of Eadyn. Moreover, the AUHSROC for the sensitivity analysis of prospective studies was comparable to that in the primary analysis.ConclusionsEadyn exhibits good performance for predicting MAP increases in response to fluid expansion in mechanically ventilated hypotensive adults, especially in the ICU setting.
Highlights
Dynamic arterial elastance (Eadyn) has been extensively considered as a functional parameter of arterial load
Data sources and search strategy Two reviewers (Zhou X and Pan W) independently and systematically searched on the PubMed, Embase, Web of Science, and Cochrane Central Register of Controlled Trials from database inception to November 28, 2020, to retrieve studies that evaluated the association between Eadyn and mean arterial pressure (MAP) increases associated with fluid expansion in mechanically ventilated hypotensive adults, without any date or language restrictions
As the cut-off value of Eadyn varied across the included studies, we only presented the area under the hierarchical summary ROC (HSROC) curve (AUHSROC) as the main measure of diagnostic accuracy
Summary
Dynamic arterial elastance (Eadyn) has been extensively considered as a functional parameter of arterial load. Conflicting evidence has been obtained on the ability of Eadyn to predict mean arterial pressure (MAP) changes after fluid expansion. This meta-analysis sought to assess the predictive performance of E adyn for the MAP response to fluid expansion in mechanically ventilated hypotensive patients. Fluid responsiveness is an indicator of great concern for physicians during fluid resuscitation For those patients who remain hypotensive and fluidresponsive after receiving an arbitrary amount of fluid, clinicians will generally continue to infuse fluid to reach the minimum mean arterial pressure (MAP). Merely assessing fluid responsiveness to predict MAP increases in response to fluid expansion is not risk free, and arterial load is the other key factor that determines MAP changes in response to fluid administration. Assessing arterial load before administering more fluids is essential for hypotensive patients who have received initial fluid resuscitation
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