Abstract
BackgroundThis study aimed to evaluate the clinical outcomes and assess preoperative characteristics that may predict outcomes in keratoconus 1 year after accelerated transepithelial corneal cross-linking (ATE-CXL).MethodsThis prospective study included 93 eyes of 84 consecutive keratoconus patients with 1-year follow-up after ATE-CXL. Preoperative characteristics included corneal astigmatism, anterior chamber depth, anterior chamber volume, radius of curvature, posterior elevation, central corneal thickness (CCT), thinnest corneal thickness, steepest meridian keratometry, flattest meridian keratometry, and the maximum keratometry (Kmax). Data were obtained preoperatively and at 1, 3, 6, and 12 months postoperatively. The patient eyes were grouped into 3 subgroups according to CCT and Kmax values to observe the changes of keratoconus progression.ResultsAll patients were successfully operated without complications at any follow-up time point. Mean changes of Kmax from baseline at 6 and 12 months were − 0.60 ± 2.21 D (P = 0.011) and − 0.36 ± 1.58 D (P = 0.030), respectively. Eyes with a thinner CCT and higher Kmax values exhibited a tendency for topographic flattening of ≥1.0 D (P = 0.003; P = 0.003). In the subgroup comparison, the Kmax values decreased significantly at 6 and 12 months after ATE-CXL in the group with CCT ≤ 450 μm (P = 0.018 and P = 0.045); the Kmax values of the group with Kmax > 65.0 D decreased significantly at 6 months postoperatively (P = 0.025).ConclusionATE-CXL is a safe and effective treatment for keratoconus patients. Patients with thinner CCT and higher Kmax values are more likely to benefit from ATE-CXL.
Highlights
This study aimed to evaluate the clinical outcomes and assess preoperative characteristics that may predict outcomes in keratoconus 1 year after accelerated transepithelial corneal cross-linking (ATE-CXL)
Accelerated transepithelial corneal cross-linking (ATE-CXL) is a treatment based on CXL, which can preserve the integrity of the cornea without removing the corneal epithelium and Bowman’s layer
No significant changes were found in best corrected visual acuity (BCVA), which was 0.32 ± 0.15 preoperatively and 0.28 ± 0.13 at 1 year post-ATE-CXL (P = 0.085)
Summary
This study aimed to evaluate the clinical outcomes and assess preoperative characteristics that may predict outcomes in keratoconus 1 year after accelerated transepithelial corneal cross-linking (ATE-CXL). Corneal cross-linking (CXL) is one of the treatments aimed at stabilizing the progression of keratoconus [2,3,4]. CXL enhances corneal hardness by increasing the covalent binding between collagen fibers [6,7,8]. Accelerated transepithelial corneal cross-linking (ATE-CXL) is a treatment based on CXL, which can preserve the integrity of the cornea without removing the corneal epithelium and Bowman’s layer (epithelium-on). It can increase patients’ cooperation by shortening the time of riboflavin infiltration
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