Predictive factors of prostate cancer at repeat biopsy in patients with elevated serum prostate-specific antigen

Abstract

Objective The predictive factors of prostate cancer at repeat biopsy in patients with elevated serum total prostate specific antigen (tPSA) after initial negative biopsy.Methods A total of 112 men with suspected prostate cancer underwent prostate biopsy.All of them were diagnosed as having negative results and received the second biopsy.They were divided into a prostate cancer group (33 cases) and a non-cancer group (79 cases) according to the final pathological diagnosis from the second biopsy.We analyzed and compared the clinical characteristics of the two groups to determine the predictors for the repeat biopsy pathology results of prostate cancer.Results There were significant differences in high grade intraepithelial neoplasm (HGPIN),PSA density (PSAD) and transitional zone volume (TZV) between the two groups.The logistic regression analysis showed that PSAD and TZV had a statistically significant correlation with cancer detection.Conclusion PSAD and TZV are predictive factors of prostate cancer in patients with an initial negative biopsy of elevated PSA levels.Early repeat biopsy is especially recommended in cases with high parameters which are mentioned above. Key words: Prostate-specific antigen ; Prostate cancer; Biopsy